Welcome to the Spatial Research lab!
Our research focuses on developing innovative experimental methods as well as novel computational tools for spatially resolved omics in mammalian and plant tissue sections.
You can find out more about our team and our academic research activities under the Research section.
NEWS
JAN 31ST 2023
STARTING 2023 WITH NEW PUBLICATIONS. We greet the new year with a new publication in Nature Communications: “Spatially resolved transcriptomic profiling of degraded and challenging fresh frozen samples“. In this article, we present a modified protocol for Visium in order to improve the mRNA recovery from more challenging fresh frozen samples, an approach we call RNA-Rescue Spatial Transcriptomics (RRST) ⛑️.
In addition, we also have a new pre-print available on bioRxiv where we demonstrate combined use of Visium, to capture mRNA, and mass spectrometry imaging, to capture metabolites, on the same tissue section: “Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues“
AUG 10TH 2022
SPATIAL CNV IN CANCER. Today, our newest publication “Spatially resolved clonal copy number alterations in benign and malignant tissue” is out it Nature! In this study, Mengxiao, Emelie, and many others from our group, embarked on a mission with our fantastic collaborators to chart the spatially resolved copy number variation in a vast number of tissue biopsies from malignant and benign tumors. Here, we demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate, suggesting a model for how genomic instability arises in histologically benign tissue that may represent early events in cancer evolution.
Image: Ludvig Larsson, Natalie Stakenborg, Joakim Lundeberg and Guy Boeckxstaens
Contact
Joakim Lundeberg
Professor
Science for Life Laboratory
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health, Dept. of Gene Technology
Tomtebodavägen 23 A
171 65 Solna, Sweden
joakim.lundeberg@scilifelab.se
Jonas Frisén
Professor
Karolinska Institutet,
Biomedicum B6,
Solnavägen 9,
171 65 Solna, Sweden
jonas.frisen@ki.se
Annelie Mollbrink
Lab manager, Ph.D
Science for Life Laboratory
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health, Dept. of Gene Technology
Tomtebodavägen 23 A
171 65 Solna, Sweden
spatialtranscriptomics@scilifelab.se
Patrik Ståhl
Assistant Professor, Ph.D
Science for Life Laboratory
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health, Dept. of Gene Technology
Tomtebodavägen 23 A
171 65 Solna, Sweden
patrik.stahl@scilifelab.se
Stefania Giacomello
Team Leader, Ph.D
Science for Life Laboratory
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health, Dept. of Gene Technology
Tomtebodavägen 23 A
171 65 Solna, Sweden
stefania.giacomello@scilifelab.se
Human Developmental
Cell Atlas (HDCA)
Paulo Czarnewski, PhD
Scientific coordinator
HDCA Sweden website
hdca-sweden@scilifelab.se
