Welcome to the Spatial Research lab!



Our research focuses on developing innovative experimental methods as well as novel computational tools for spatially resolved omics in mammalian and plant tissue sections.

You can find out more about our team and our academic research activities under the Research section.

NEWS

JAN 31ST 2023


STARTING 2023 WITH NEW PUBLICATIONS. We greet the new year with a new publication in Nature Communications: “Spatially resolved transcriptomic profiling of degraded and challenging fresh frozen samples“. In this article, we present a modified protocol for Visium in order to improve the mRNA recovery from more challenging fresh frozen samples, an approach we call RNA-Rescue Spatial Transcriptomics (RRST) ⛑️.

In addition, we also have a new pre-print available on bioRxiv where we demonstrate combined use of Visium, to capture mRNA, and mass spectrometry imaging, to capture metabolites, on the same tissue section: “Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues

AUG 10TH 2022


SPATIAL CNV IN CANCER. Today, our newest publication “Spatially resolved clonal copy number alterations in benign and malignant tissue” is out it Nature! In this study, Mengxiao, Emelie, and many others from our group, embarked on a mission with our fantastic collaborators to chart the spatially resolved copy number variation in a vast number of tissue biopsies from malignant and benign tumors. Here, we demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate, suggesting a model for how genomic instability arises in histologically benign tissue that may represent early events in cancer evolution.

“Method of the Year: Spatially resolved transcriptomics” by Nature Methods
Image: Ludvig Larsson, Natalie Stakenborg, Joakim Lundeberg and Guy Boeckxstaens

Contact

Joakim Lundeberg
Professor




Science for Life Laboratory
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health, Dept. of Gene Technology

Tomtebodavägen 23 A
171 65 Solna, Sweden


joakim.lundeberg@scilifelab.se

Jonas Frisén
Professor




Karolinska Institutet,
Biomedicum B6,
Solnavägen 9,
171 65 Solna, Sweden


jonas.frisen@ki.se

Annelie Mollbrink
Lab manager, Ph.D




Science for Life Laboratory
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health, Dept. of Gene Technology

Tomtebodavägen 23 A
171 65 Solna, Sweden


spatialtranscriptomics@scilifelab.se

Patrik Ståhl
Assistant Professor, Ph.D




Science for Life Laboratory
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health, Dept. of Gene Technology

Tomtebodavägen 23 A
171 65 Solna, Sweden


patrik.stahl@scilifelab.se

Stefania Giacomello
Team Leader, Ph.D



Science for Life Laboratory
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health, Dept. of Gene Technology

Tomtebodavägen 23 A
171 65 Solna, Sweden


stefania.giacomello@scilifelab.se

Human Developmental
Cell Atlas (HDCA)



Paulo Czarnewski, PhD
Scientific coordinator


HDCA Sweden website


hdca-sweden@scilifelab.se