Frisén lab

Jonas Frisén
Professor, Principal Investigator, KI
Email: jonas.frisen@ki.se

Research focus

We are interested in the role of stem cells in cell turnover in healthy and pathological situations. We study the identity of stem cells and the organization of cellular lineages, the molecular regulation of cell production and the role of cell renewal in homeostasis and pathological situations. Many of our projects focus on stem cells in the brain and spinal cord and adult neurogenesis.

We are also interested in cell renewal in the heart and use the intestine as a stem cell and cancer model system. We have developed a method to study cell turnover by analyzing the integration of 14C derived from nuclear bomb tests in DNA, and use this to assess cell renewal in humans.


External websites

https://ki.se/en/cmb/jonas-frisens-group
http://www.frisenlab.org

Key publications

High-definition spatial transcriptomics for in situ tissue profiling
Vickovic S, Eraslan G, Salmén F, Klughammer J, Stenbeck L, Schapiro D, Äijö T, Bonneau R, Bergenstråhle L, Navarro JF, Gould J, Griffin GK, Borg Å, Ronaghi M, Frisén J, Lundeberg J, Regev A, Ståhl PL
Nature Methods (2019)

Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing
Hård J, Al Hakim E, Kindblom M, Björklund ÅK, Sennblad B, Demirci I, Paterlini M, Reu P, Borgström E, Ståhl PL, Michaelsson J, Mold JE, Frisén J
Genome Biology (2019)

Dynamics of oligodendrocyte generation in multiple sclerosis
Yeung MSY, Djelloul M, Steiner E, Bernard S, Salehpour M, Possnert G, Brundin L, Frisén J
Nature (2019)

Barcoded solid-phase RNA capture for Spatial Transcriptomics profiling in mammalian tissue sections
Salmén F, Ståhl PL, Mollbrink A, Navarro JF, Vickovic S, Frisén J, Lundeberg J
Nature Protocol (2018)

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
Dias DO, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlén M, Göritz C, Frisén J
Cell (2018)

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Ståhl PL, Salmén F, Vickovic S, Lundmark A, Navarro JF, Magnusson J, Giacomello S, Asp M, Westholm JO, Huss M, Mollbrink A, Linnarsson S, Codeluppi S, Borg Å, Pontén F, Costea PI, Sahlén P, Mulder J, Bergmann O, Lundeberg J, Frisén J
Science (2016)

Dynamics of cell generation and turnover in the human heart
Bergmann O, Zdunek S, Felker A, Salehpour M, Alkass K, Bernard S, Sjostrom SL, Szewczykowska M, Jackowska T, Dos Remedios C, Malm T, Andrä M, Jashari R, Nyengaard JR, Possnert G, Jovinge S, Druid H, Frisén J
Cell (2015)

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth
Kundu P, Genander M, Strååt K, Classon J, Ridgway RA, Tan EH, Björk J, Martling A, van Es J, Sansom OJ, Clevers H, Pettersson S, Frisén J
Science translational medicine (2015)

Dynamics of oligodendrocyte generation and myelination in the human brain
Yeung MS, Zdunek S, Bergmann O, Bernard S, Salehpour M, Alkass K, Perl S, Tisdale J, Possnert G, Brundin L, Druid H, Frisén J
Cell (2014)

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse
Magnusson JP, Göritz C, Tatarishvili J, Dias DO, Smith EM, Lindvall O, Kokaia Z, Frisén J
Science (2014)

The age and genomic integrity of neurons after cortical stroke in humans
Huttner HB, Bergmann O, Salehpour M, Rácz A, Tatarishvili J, Lindgren E, Csonka T, Csiba L, Hortobágyi T, Méhes G, Englund E, Solnestam BW, Zdunek S, Scharenberg C, Ström L, Ståhl P, Sigurgeirsson B, Dahl A, Schwab S, Possnert G, Bernard S, Kokaia Z, Lindvall O, Lundeberg J, Frisén J
Nature neuroscience (2014)

Neurogenesis in the striatum of the adult human brain
Ernst A, Alkass K, Bernard S, Salehpour M, Perl S, Tisdale J, Possnert G, Druid H, Frisén J
Cell (2014)

Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice
Sabelström H, Stenudd M, Réu P, Dias DO, Elfineh M, Zdunek S, Damberg P, Göritz C, Frisén J
Science (2013)

Dynamics of hippocampal neurogenesis in adult humans
Spalding KL, Bergmann O, Alkass K, Bernard S, Salehpour M, Huttner HB, Boström E, Westerlund I, Vial C, Buchholz BA, Possnert G, Mash DC, Druid H, Frisén J
Cell (2013)

Why adults need new brain cells
Bergmann O, Frisén J
Science (2013)

A pericyte origin of spinal cord scar tissue
Göritz C, Dias DO, Tomilin N, Barbacid M, Shupliakov O, Frisén J
Science (2011)

Origin of new glial cells in intact and injured adult spinal cord
Barnabé-Heider F, Göritz C, Sabelström H, Takebayashi H, Pfrieger FW, Meletis K, Frisén J
Cell Stem Cell (2010)

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression
Genander M, Halford MM, Xu NJ, Eriksson M, Yu Z, Qiu Z, Martling A, Greicius G, Thakar S, Catchpole T, Chumley MJ, Zdunek S, Wang C, Holm T, Goff SP, Pettersson S, Pestell RG, Henkemeyer M, Frisén J
Cell (2009)

Evidence for cardiomyocyte renewal in humans
Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisén J
Science (2009)

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Carlén M, Meletis K, Göritz C, Darsalia V, Evergren E, Tanigaki K, Amendola M, Barnabé-Heider F, Yeung MS, Naldini L, Honjo T, Kokaia Z, Shupliakov O, Cassidy RM, Lindvall O, Frisén J
Nature Neuroscience (2009)